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Amplicon | Whole genome | |
|---|---|---|
Dataset size | Very small | Medium to very large |
Computational resources | Small | Medium to very large |
Price | Low | Medium to high |
Taxonomic resolution | Mostly genus | Species or strain |
Functional analysis | Limited | Greater detail |
Database curation | Detailed | Minimal |
Taxonomic coverage | Specific (e.g. 16s = bacteria) | All taxa |
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Analysis of the microbiome: Advantages of whole genome shotgun versus 16S amplicon sequencing
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